Recent Progress in RXLR Effector Research.
Identifieur interne : 000D81 ( Main/Exploration ); précédent : 000D80; suivant : 000D82Recent Progress in RXLR Effector Research.
Auteurs : Ryan G. Anderson [États-Unis] ; Devdutta Deb [États-Unis] ; Kevin Fedkenheuer [États-Unis] ; John M. Mcdowell [États-Unis]Source :
- Molecular plant-microbe interactions : MPMI [ 0894-0282 ] ; 2015.
Descripteurs français
- KwdFr :
- Interactions hôte-pathogène (MeSH), Maladies des plantes (immunologie), Maladies des plantes (microbiologie), Motifs d'acides aminés (MeSH), Oomycetes (génétique), Oomycetes (pathogénicité), Oomycetes (physiologie), Peronospora (génétique), Peronospora (pathogénicité), Peronospora (physiologie), Phytophthora (génétique), Phytophthora (pathogénicité), Phytophthora (physiologie), Plantes (immunologie), Plantes (microbiologie), Protéines (génétique), Protéines (métabolisme), Transport des protéines (MeSH), Virulence (MeSH), Évolution biologique (MeSH).
- MESH :
- génétique : Oomycetes, Peronospora, Phytophthora, Protéines.
- immunologie : Maladies des plantes, Plantes.
- microbiologie : Maladies des plantes, Plantes.
- métabolisme : Protéines.
- pathogénicité : Oomycetes, Peronospora, Phytophthora.
- physiologie : Oomycetes, Peronospora, Phytophthora.
- Interactions hôte-pathogène, Motifs d'acides aminés, Transport des protéines, Virulence, Évolution biologique.
English descriptors
- KwdEn :
- Amino Acid Motifs (MeSH), Biological Evolution (MeSH), Host-Pathogen Interactions (MeSH), Oomycetes (genetics), Oomycetes (pathogenicity), Oomycetes (physiology), Peronospora (genetics), Peronospora (pathogenicity), Peronospora (physiology), Phytophthora (genetics), Phytophthora (pathogenicity), Phytophthora (physiology), Plant Diseases (immunology), Plant Diseases (microbiology), Plants (immunology), Plants (microbiology), Protein Transport (MeSH), Proteins (genetics), Proteins (metabolism), Virulence (MeSH).
- MESH :
- chemical , genetics : Proteins.
- genetics : Oomycetes, Peronospora, Phytophthora.
- immunology : Plant Diseases, Plants.
- chemical , metabolism : Proteins.
- microbiology : Plant Diseases, Plants.
- pathogenicity : Oomycetes, Peronospora, Phytophthora.
- physiology : Oomycetes, Peronospora, Phytophthora.
- Amino Acid Motifs, Biological Evolution, Host-Pathogen Interactions, Protein Transport, Virulence.
Abstract
Some of the most devastating oomycete pathogens deploy effector proteins, with the signature amino acid motif RXLR, that enter plant cells to promote virulence. Research on the function and evolution of RXLR effectors has been very active over the decade that has transpired since their discovery. Comparative genomics indicate that RXLR genes play a major role in virulence for Phytophthora and downy mildew species. Importantly, gene-for-gene resistance against these oomycete lineages is based on recognition of RXLR proteins. Comparative genomics have revealed several mechanisms through which this resistance can be broken, most notably involving epigenetic control of RXLR gene expression. Structural studies have revealed a core fold that is present in the majority of RXLR proteins, providing a foundation for detailed mechanistic understanding of virulence and avirulence functions. Finally, functional studies have demonstrated that suppression of host immunity is a major function for RXLR proteins. Host protein targets are being identified in a variety of plant cell compartments. Some targets comprise hubs that are also manipulated by bacteria and fungi, thereby revealing key points of vulnerability in the plant immune network.
DOI: 10.1094/MPMI-01-15-0022-CR
PubMed: 26125490
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Anderson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA, U.S.A.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Deb, Devdutta" sort="Deb, Devdutta" uniqKey="Deb D" first="Devdutta" last="Deb">Devdutta Deb</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA, U.S.A.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Fedkenheuer, Kevin" sort="Fedkenheuer, Kevin" uniqKey="Fedkenheuer K" first="Kevin" last="Fedkenheuer">Kevin Fedkenheuer</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA, U.S.A.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Mcdowell, John M" sort="Mcdowell, John M" uniqKey="Mcdowell J" first="John M" last="Mcdowell">John M. Mcdowell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA, U.S.A.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author></analytic><series><title level="j">Molecular plant-microbe interactions : MPMI</title><idno type="ISSN">0894-0282</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Motifs (MeSH)</term><term>Biological Evolution (MeSH)</term><term>Host-Pathogen Interactions (MeSH)</term><term>Oomycetes (genetics)</term><term>Oomycetes (pathogenicity)</term><term>Oomycetes (physiology)</term><term>Peronospora (genetics)</term><term>Peronospora (pathogenicity)</term><term>Peronospora (physiology)</term><term>Phytophthora (genetics)</term><term>Phytophthora (pathogenicity)</term><term>Phytophthora (physiology)</term><term>Plant Diseases (immunology)</term><term>Plant Diseases (microbiology)</term><term>Plants (immunology)</term><term>Plants (microbiology)</term><term>Protein Transport (MeSH)</term><term>Proteins (genetics)</term><term>Proteins (metabolism)</term><term>Virulence (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Interactions hôte-pathogène (MeSH)</term><term>Maladies des plantes (immunologie)</term><term>Maladies des plantes (microbiologie)</term><term>Motifs d'acides aminés (MeSH)</term><term>Oomycetes (génétique)</term><term>Oomycetes (pathogénicité)</term><term>Oomycetes (physiologie)</term><term>Peronospora (génétique)</term><term>Peronospora (pathogénicité)</term><term>Peronospora (physiologie)</term><term>Phytophthora (génétique)</term><term>Phytophthora (pathogénicité)</term><term>Phytophthora (physiologie)</term><term>Plantes (immunologie)</term><term>Plantes (microbiologie)</term><term>Protéines (génétique)</term><term>Protéines (métabolisme)</term><term>Transport des protéines (MeSH)</term><term>Virulence (MeSH)</term><term>Évolution biologique (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Oomycetes</term><term>Peronospora</term><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Oomycetes</term><term>Peronospora</term><term>Phytophthora</term><term>Protéines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Maladies des plantes</term><term>Plantes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Plant Diseases</term><term>Plants</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proteins</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des plantes</term><term>Plantes</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Diseases</term><term>Plants</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Oomycetes</term><term>Peronospora</term><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Oomycetes</term><term>Peronospora</term><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Oomycetes</term><term>Peronospora</term><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Oomycetes</term><term>Peronospora</term><term>Phytophthora</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Motifs</term><term>Biological Evolution</term><term>Host-Pathogen Interactions</term><term>Protein Transport</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Interactions hôte-pathogène</term><term>Motifs d'acides aminés</term><term>Transport des protéines</term><term>Virulence</term><term>Évolution biologique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Some of the most devastating oomycete pathogens deploy effector proteins, with the signature amino acid motif RXLR, that enter plant cells to promote virulence. Research on the function and evolution of RXLR effectors has been very active over the decade that has transpired since their discovery. Comparative genomics indicate that RXLR genes play a major role in virulence for Phytophthora and downy mildew species. Importantly, gene-for-gene resistance against these oomycete lineages is based on recognition of RXLR proteins. Comparative genomics have revealed several mechanisms through which this resistance can be broken, most notably involving epigenetic control of RXLR gene expression. Structural studies have revealed a core fold that is present in the majority of RXLR proteins, providing a foundation for detailed mechanistic understanding of virulence and avirulence functions. Finally, functional studies have demonstrated that suppression of host immunity is a major function for RXLR proteins. Host protein targets are being identified in a variety of plant cell compartments. Some targets comprise hubs that are also manipulated by bacteria and fungi, thereby revealing key points of vulnerability in the plant immune network. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26125490</PMID><DateCompleted><Year>2016</Year><Month>01</Month><Day>07</Day></DateCompleted><DateRevised><Year>2015</Year><Month>10</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0894-0282</ISSN><JournalIssue CitedMedium="Print"><Volume>28</Volume><Issue>10</Issue><PubDate><Year>2015</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Molecular plant-microbe interactions : MPMI</Title><ISOAbbreviation>Mol Plant Microbe Interact</ISOAbbreviation></Journal><ArticleTitle>Recent Progress in RXLR Effector Research.</ArticleTitle><Pagination><MedlinePgn>1063-72</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1094/MPMI-01-15-0022-CR</ELocationID><Abstract><AbstractText>Some of the most devastating oomycete pathogens deploy effector proteins, with the signature amino acid motif RXLR, that enter plant cells to promote virulence. Research on the function and evolution of RXLR effectors has been very active over the decade that has transpired since their discovery. Comparative genomics indicate that RXLR genes play a major role in virulence for Phytophthora and downy mildew species. Importantly, gene-for-gene resistance against these oomycete lineages is based on recognition of RXLR proteins. Comparative genomics have revealed several mechanisms through which this resistance can be broken, most notably involving epigenetic control of RXLR gene expression. Structural studies have revealed a core fold that is present in the majority of RXLR proteins, providing a foundation for detailed mechanistic understanding of virulence and avirulence functions. Finally, functional studies have demonstrated that suppression of host immunity is a major function for RXLR proteins. Host protein targets are being identified in a variety of plant cell compartments. Some targets comprise hubs that are also manipulated by bacteria and fungi, thereby revealing key points of vulnerability in the plant immune network. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Ryan G</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA, U.S.A.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deb</LastName><ForeName>Devdutta</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA, U.S.A.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fedkenheuer</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA, U.S.A.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McDowell</LastName><ForeName>John M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Physiology, and Weed Science, Virginia Tech, Blacksburg, VA, U.S.A.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>10</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Plant Microbe Interact</MedlineTA><NlmUniqueID>9107902</NlmUniqueID><ISSNLinking>0894-0282</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011506">Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D020816" MajorTopicYN="N">Amino Acid Motifs</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005075" MajorTopicYN="N">Biological Evolution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="Y">Host-Pathogen Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009868" MajorTopicYN="N">Oomycetes</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044742" MajorTopicYN="N">Peronospora</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010944" MajorTopicYN="N">Plants</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D021381" MajorTopicYN="N">Protein Transport</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011506" MajorTopicYN="N">Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>1</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26125490</ArticleId><ArticleId 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Anderson</name></region><name sortKey="Deb, Devdutta" sort="Deb, Devdutta" uniqKey="Deb D" first="Devdutta" last="Deb">Devdutta Deb</name><name sortKey="Fedkenheuer, Kevin" sort="Fedkenheuer, Kevin" uniqKey="Fedkenheuer K" first="Kevin" last="Fedkenheuer">Kevin Fedkenheuer</name><name sortKey="Mcdowell, John M" sort="Mcdowell, John M" uniqKey="Mcdowell J" first="John M" last="Mcdowell">John M. Mcdowell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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